To lock a drawing tablet to a single monitor, the command is

xinput map-to-output $STYLUS $MONITOR

where $STYLUS is gottten from xinput:

❯ xinput
⎡ Virtual core pointer                    	id=2	[master pointer  (3)]
⎜   ↳ ...
⎜   ↳ HID 256c:006d Pen Pen (0)               	id=26	[slave  pointer  (2)]
⎜   ↳ ...
⎣ Virtual core keyboard                   	id=3	[master keyboard (2)]
    ↳ ...

and $MONITOR is gotten from xrandr:

❯ xrandr --listactivemonitors
Monitors: 3
 0: +*DP-1-2 3840/621x2160/341+0+0  DP-1-2
 1: +eDP1 1920/340x1080/190+3840+1440  eDP1
 2: +HDMI-1-0 2560/530x1440/290+3840+0  HDMI-1-0

Reference: StackOverflow